Traumatic Brain Injury Research Group

Aims

Turku Traumatic Brain Injury Research Group’s research is focused on clinical, translational, and epidemiological research on neurotraumatology. The group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently active research collaboration with ten national and 22 international (from 13 countries) research groups.

Group Members

Senior Researchers:

• Jussi Hirvonen, MD, PhD, Prof. (radiology)
• Janek Frantzén, MD, PhD, Adj. Prof. (neurosurgery)
• Timo Kurki, MD, PhD, Adj. Prof (radiology)
• Riikka Takala, MD, PhD, Adj. Prof. (anesthesiology)
• Iftakher Hossain, MD, PhD
• Timo Roine, PhD
• Michael Wilson, PhD
• Mehrbod Mohammadian, PhD
• Anna Östberg, MD, PhD

Doctoral Students:

• Mari Saarinen
• Niklas Särkilahti
• Peter Ngum
• Iisa Mansikka
• Pia Koivikko
• Minttu Hellman
• Nina Erkinjuntti
• Matti Artosalo
• Ari Katila
• Shkar Maruf
• Jussi Tallus
• Aaron Rintala
• Marjaana Raukola-Lindblom
• Emmi Arekallio
• Aura Kartio
• Malla Mononen
• Otto Korhonen
• Katja Malmi
• Henna-Riikka Maanpää
• Toni Niiranen
• Saku Ketonen
• Anne Abio
• Martta Hartikainen
• Herman Lule

Collaborators & Partners

• Kaj Blennow, Sahlgrenska Academy at University of Gothenburg, Sweden
• Peter Hutchinson, University of Cambridge, United Kingdom
• Grant L. Iverson, Harvard Medical School, United States
• Geoffrey Manley, UCSF, San Francisco, CA, United States
• David K. Menon, University of Cambridge, United Kingdom
• Stefania Mondello, University of Messina, Italy
• Matej Orešič, University of Örebro, Sweden, and University of Turku, Finland
• Jean-Charles Sanchez, University of Geneva, Switzerland
• Henrik Zetterberg, Sahlgrenska Academy at University of Gothenburg, Sweden

Main Funding

• Sigrid Jusélius Foundation
• Academy of Finland
• European Commission under the 7th Framework Programme
• Maire Taponen Foundation
• State Research Funding, Finland

Selected Publications

1. Posti JP, Ruuskanen JO, Kytö V. Adult-onset epilepsy and risk of traumatic brain injury: A nationwide cohort study. J Neurol Neurosurg Psychiatry. 2022 Nov 30:jnnp-2022-330150.
2. Kolias AG, Adams H, Timofee IS, Corteen EA, Hossain I, Czosnyka M, Timothy J, Anderson I, Bulters DO, Belli A, Eynon CA, Wadley J, Mendelow D, Mitchell PM, Wilson MH, Critchley G, Sahuquillo J, Unterberg A, Posti JP, Servadei F, Teasdale GM, Pickard JD, Menon DK, Murray GD, Kirkpatrick PJ, Hutchinson PJ, RESCUEicp Trial Collaborators. Outcomes of Decompressive Craniectomy Compared to Medical Treatment for Traumatic Intracranial Hypertension at 2 Years: A Secondary Analysis of the RESCUEicp Randomized Trial. JAMA Neurol. 2022 Jul 1;79(7):664-671.
3. Posti JP, Ruuskanen JO, Sipilä JOT, Luoto TM, Rautava P, Kytö V. Effect of Oral Anticoagulation and Adenosine Diphosphate Inhibitor Therapies on Short-term Outcome of Traumatic Brain Injury. Neurology. 2022 Jun 28:10.1212
4. Thomas I, Dickens AM, Posti JP, Czeiter E, Duberg D, Sinioja T, Kråkström M, Retel Helmrich IRA, Wang KKW, Maas AIR, Steyerberg EW, Menon DK, Tenovuo O, Hyötyläinen T, Büki A, Orešič M; CENTER-TBI Participants and Investigators. Serum metabolome associated with severity of acute traumatic brain injury. Nat Commun. 2022 May 10;13(1):2545.
5. Newcombe VFJ, Ashton NJ, Posti JP, Glocker B, Manktelow A, Chatfield DA, Winzeck S, Needham E, Correia MM, Williams GB, Simrén J, Takala RSK, Katila AJ, Maanpää HR, Tallus J, Frantzén J, Blennow K, Tenovuo O, Zetterberg H, Menon DK. Post-acute blood biomarkers and disease progression in traumatic brain injury. Brain. 2022 Apr 4:awac126.
6. Roine T, Mohammadian M, Hirvonen J, Kurki T, Posti JP, Takala RSK, Newcombe VF, Tallus J, Katila AJ, Maanpää HR, Frantzen J, Menon D, Tenovuo O. Structural Brain Connectivity Correlates with Outcome in Mild Traumatic Brain Injury. J Neurotrauma. 2022 Jan 26.
7. Iaccarino C, Kolias A, Adelson PD, Rubiano AM, Viaroli E, Buki A, Cinalli G, Fountas K, Khan T, Signoretti S, Waran V, Adeleye AO, Amorim R, Bertuccio A, Cama A, Chesnut RM, De Bonis P, Estraneo A, Figaji A, Florian SI, Formisano R, Frassanito P, Gatos C, Germanò A, Giussani C, Hossain I, Kasprzak P, La Porta F, Lindner D, Maas AIR, Paiva W, Palma P, Park KB, Peretta P, Pompucci A, Posti J, Sengupta SK, Sinha A, Sinha V, Stefini R, Talamonti G, Tasiou A, Zona G, Zucchelli M, Hutchinson PJ, Servadei F. Consensus statement from the international consensus meeting on post-traumatic cranioplasty. Acta Neurochir (Wien). 2021 Feb;163(2):423-440
8. Posti JP, Takala RSK, Lagerstedt L, Hossain MI, Mohammadian M, Dickens AM, Ala-Seppälä, H, Katila A, Kyllönen A, Maanpää HR, Tallus J, van Gils M, Hutchinson P, Menon DK, Blennow K, Gill J, Sanchez JC, Tenovuo O, Zetterberg H, Blennow K. Correlation of novel blood-based protein biomarkers with intracranial findings on CT after traumatic brain injury. J Neurotrauma. 2019 Jul 15;36(14):2178-2189.
9. Hossain I, Mohammadian M, Takala RSK, Tenovuo O, Ala-Seppälä H, Blennow K, Katila AJ, Kyllönen A, Lagerstedt L, Maanpää HR, Sanchez JC, Tallus J, van Gils M, Zetterberg H, Hutchinson P, Menon DK, Posti JP. Early levels of GFAP and NF-L in predicting the outcome of mild traumatic brain injury. J Neurotrauma. 2019 Jan 8.
10. Orešič M, Posti JP, Kamstrup-Nielsen MH, Takala RSK, Lingsma HF, Mattila I, Jäntti S, Katila AJ, Carpenter KLH, Ala-Seppälä H, Kyllönen A, Maanpää HR, Tallus J, Coles JP, Heino I, Frantzén J, Hutchinson PJ, Menon DK, Tenovuo O, Hyötyläinen T. EBioMedicine. Human serum metabolites associate with severity and patient outcomes in traumatic brain injury. EBioMedicine. 10/2016;12:118-126