Neurosurgical Neurovascular Research Group

Group Leader

Jaakko Rinne, MD, PhD, eMBA

Professor of Neurosurgery, Head of Neurocenter, Turku University Hospital and Division of Clinical Neurosciences, University of Turku

jaakko.rinne@utu.fi

Personal Page

Aims

Turku Neurosurgical Neurovascular Research Group is focusing on all aspects of subarachnoid hemorrhage and intracranial aneurysms. Our group is a multimodal network of experts from different fields of medicine. Our collaboration is both nationwide and international.

 

Group Members

Senior Researchers:

  • Melissa Rahi, MD, PhD, adj.prof (neurosurgery)
  • Juri Kivelev, MD, PhD, adj. prof. (neurosurgery)
  • Dan Laukka MD, PhD * Johanna Kuhmonen, MD, PhD
  • Riitta Rautio, MD, PhD, adj. prof. (radiology)
  • Riitta Parkkola, MD, PhD, professor (neuroradiology)
  • Antti Saraste, MD, PhD, professor (cardiology)
  • Janne Koskimäki, MD, PhD, adj prof (experimental neurosurgery)

Doctoral Students:

  • Jooa Paturi, MD
  • Janne Luotonen, MD

 

Collaborators & Partners

  • Issam A Awad, University of Chicago, Ill., USA

 

Main Funding

  • Turku University Hospital, VTR –funding
  • Maire Taponen fund
  • Pro Humanitae fund

 

Selected Publications

  1. Laukka D, Parkkola R, Hirvonen J, Ylikotila P, Vahlberg T, Salo E, Kivelev J, Rinne J, Rahi M Brain white matter hyperintensities in Kawasaki disease: A case-control study. Front Neurosci 2022 Oct 18;16:995480. doi:10.3389/fnins.2022.995480.eCollection 2022
  2. van der Kamp LT, Rinkel GJE, Verbaan D, van den Berg R, Vandertop WP, Murayama Y, Ishibashi T, Lindgren A, Koivisto T, Teo M, St George J, Agid R, Radovanovic I, Moroi J, Igase K, van den Wijngaard IR, Rahi M, Rinne J, Kuhmonen J, Boogaarts HD, Wong GKC, Abrigo JM, Morita A, Shiokawa Y, Hackenberg KAM, Etminan N, van der Schaaf IC, Zuithoff NPA, Vergouwen MDI.Risk of Rupture After Intracranial Aneurysm Growth JAMA Neurol. 2021 Aug 30. doi: 10.1001/jamaneurol.2021.2915. Online ahead of print
  3. Sajanti A, Lyne SB, Girard R, Frantzén J, Rantamäki T, Heino I, Cao Y, Diniz C, Umemori J, Li Y, Takala R, Posti JP, Roine S, Koskimäki F, Rahi M, Rinne J, Castrén E, Koskimäki J. A comprehensive p75 neurotrophin receptor gene network and pathway analyses identifying new target genes. Sci Rep. 2020 Sep 11;10(1):14984. doi: 10.1038/s41598-020-72061-z.PMID: 32917932 Free PMC article.
  4. Sánchez van Kammen M, Greving JP, Kuroda S, Kashiwazaki D, Morita A, Shiokawa Y, Kimura T, Cognard C, Januel AC, Lindgren A, Koivisto T, Jääskeläinen JE, Ronkainen A, Pyysalo L, Öhman J, Rahi M, Kuhmonen J, Rinne J, Leemans EL, Majoie CB, Vandertop WP, Verbaan D, Roos YBWEM, Berg RVD, Boogaarts HD, Moudrous W, Wijngaard IRVD, Hove LT, Teo M, George EJS, Hackenberg KAM, Abdulazim A, Etminan N, Rinkel GJE, Vergouwen MDI. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk. J Stroke. 2019 Sep;21(3):340-346. doi: 10.5853/jos.2019.01277. Epub 2019 Sep 30. PMID: 31590478; PMCID: PMC6780020.
  5. Laukka D, Pan E, Fordell T, Alpay K, Rahi M, Hirvonen J, Rinne J, Gunn J. Prevalence of thoracic aortic aneurysms and dilatations in patients with intracranial aneurysms. J Vasc Surg. 2019 Dec;70(6):1801-1808. doi: 10.1016/j.jvs.2019.01.066. Epub 2019 Jul 18. PMID: 31327605
  6. Laukka D, Rahi M, Parkkola R, Vahlberg T, Rintala A, Salo E, Rinne J. Unlikely association between Kawasaki disease and intracranial aneurysms: a prospective cohort study. J Neurosurg Pediatr. 2019 Feb 15:1-4. doi: 10.3171/2018.11.PEDS18575. [Epub ahead of print] PMID: 30771761
  7. Lindgren, A.E., Kurki, M.I., Riihinen, A., Koivisto, T., Ronkainen, A., Rinne, J., Hernesniemi, J., Eriksson, J.G., Jääskeläinen, J.E., von Und zu Fraunberg, M.: Hypertension predisposes to the formation of saccular intracranial aneurysms in 467 unruptured and 1053 ruptured patients in Eastern Finland. Ann Med 46(3):169-76, 2014- Epub 2014 Mar 3.