Turku Traumatic Brain Injury Research Group

Group Leaders

 

Jussi Posti, MD, PhD

Adjunct Professor of Neurosurgery and Neurotraumatology, Head of Department
Neurocenter, Turku University Hospital; Division of Clinical Neurosciences, University of Turku

jussi.posti@utu.fi

Personal Page

 

Iftakher Ifti Hossain, MD, PhD

Senior Clinical Research Phyisician
Neurocenter, Department of Neurosurgery, Turku University Hospital
Division of Clinical Neurosciences, University of Turku
Fellow, Division of Academic Neurosurgery
University of Cambridge and Addenbrooke’s Hospital

ifthos@utu.fi

Personal Page

Aims

Turku Traumatic Brain Injury Research Group’s research is focused on clinical, translational, and epidemiological research on neurotraumatology. The group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently active research collaboration with ten national and 22 international (from 13 countries) research groups.

 

Group Members

Senior Researchers:

  • Olli Tenovuo, MD, PhD, Prof. Emeritus
  • Jussi Hirvonen, MD, PhD, Prof. (radiology)
  • Janek Frantzén, MD, PhD, Adj. Prof. (neurosurgery)
  • Timo Kurki, MD, PhD, Adj. Prof (radiology)
  • Riikka Takala, MD, PhD, Adj. Prof. (anesthesiology)
  • Timo Roine, PhD
  • Michael Wilson, PhD
  • Mehrbod Mohammadian, PhD
  • Anna Östberg, MD, PhD

Doctoral Students:

  • Mari Saarinen
  • Niklas Särkilahti
  • Peter Ngum
  • Iisa Mansikka
  • Pia Koivikko
  • Minttu Hellman
  • Nina Erkinjuntti
  • Matti Artosalo
  • Ari Katila
  • Shkar Maruf
  • Jussi Tallus
  • Aaron Rintala
  • Marjaana Raukola-Lindblom
  • Emmi Arekallio
  • Aura Kartio
  • Malla Mononen
  • Otto Korhonen
  • Katja Malmi
  • Henna-Riikka Maanpää
  • Toni Niiranen
  • Saku Ketonen
  • Anne Abio
  • Martta Hartikainen
  • Herman Lule

 

Collaborators & Partners

  • Peter Hutchinson, University of Cambridge, United Kingdom
  • Grant L. Iverson, Harvard Medical School, United States
  • Geoffrey Manley, UCSF, San Francisco, CA, United States
  • David K. Menon, University of Cambridge, United Kingdom
  • Stefania Mondello, University of Messina, Italy
  • Matej Orešič, University of Örebro, Sweden, and University of Turku, Finland
  • Jean-Charles Sanchez, University of Geneva, Switzerland
  • Ramon Diaz-Arrastia, University of Pennsylvania Perelman School of Medicine, Philadelphia, USA
  • Niklas Marklund, University of Lund, Lund, Sweden

 

Main Funding

  • Sigrid Jusélius Foundation
  • Academy of Finland
  • European Commission under the 7th Framework Programme
  • Maire Taponen Foundation
  • State Research Funding, Finland
  • Finnish Medical Foundation
  • Paulo Foundation
  • Orion Research Foundation

 

Selected Publications

  1. Samanta RJ, Chiollaz AC, Needham E, Yue JK, Helmy A, Zanier ER, Wang KKW, Kobeissy F, Posti JP, Summers C, Manley GT, Maas AI, Tenovuo O, Sanchez JC, Menon DK; TRACK-TBI investigators and participants; CENTER-TBI investigators and participants. Parsimonious immune-response endotypes and global outcome in patients with traumatic brain injury. EBioMedicine. 2024 Sep 17;108:105310.
  2. Raj R, Tommiska P, Koivisto T, Leinonen V, Danner N, Posti JP, Laukka D, Luoto T, Rauhala M, Tetri S, Korhonen TK, Satopää J, Kivisaari R, Luostarinen T, Schwartz C, Czuba T, Taimela S, Lönnrot K, Järvinen TLN; Finnish study of intraoperative irrigation versus drain alone after evacuation of CSDH (FINISH) study group. Burr-hole drainage with or without irrigation for chronic subdural haematoma (FINISH): a Finnish, nationwide, parallel-group, multicentre, randomised, controlled, non-inferiority trial. Lancet. 2024 Jun 29;403(10446):2798-2806. doi: 10.1016/S0140-6736(24)00686-X.
  3. Korhonen O, Mononen M, Mohammadian M, Tenovuo O, Blennow K, Hossain I, Hutchinson P, Maanpää HR, Menon DK, Virginia VFJ, MD, PhD7, Sanchez JC, Takala RSK, Tallus J, van Gils M, Zetterberg H, Posti JP. An outlier analysis for acute blood biomarkers of moderate and severe traumatic brain injury. J Neurotrauma. 2024 Jan.
  4. Hossain I, Mohammadian M, Maanpää HR, Takala RSK, Tenovuo O, Blennow K, Tallus J, van Gils M, Virginia VFJ, Menon DK, Zetterberg H, Hutchinson P, Posti JP. Plasma neurofilament light admission levels and development of axonal pathology in mild traumatic brain injury. BMC Neurology. 2023 Aug 15.
  5. Kolias AG, Adams H, Timofee IS, Corteen EA, Hossain I, Czosnyka M, Timothy J, Anderson I, Bulters DO, Belli A, Eynon CA, Wadley J, Mendelow D, Mitchell PM, Wilson MH, Critchley G, Sahuquillo J, Unterberg A, Posti JP, Servadei F, Teasdale GM, Pickard JD, Menon DK, Murray GD, Kirkpatrick PJ, Hutchinson PJ, RESCUEicp Trial Collaborators. Outcomes of Decompressive Craniectomy Compared to Medical Treatment for Traumatic Intracranial Hypertension at 2 Years: A Secondary Analysis of the RESCUEicp Randomized Trial. JAMA Neurol. 2022 Jul 1;79(7):664-671.
  6. Posti JP, Ruuskanen JO, Sipilä JOT, Luoto TM, Rautava P, Kytö V. Effect of Oral Anticoagulation and Adenosine Diphosphate Inhibitor Therapies on Short-term Outcome of Traumatic Brain Injury. Neurology. 2022 Jun 28:10.1212.
  7. Thomas I, Dickens AM, Posti JP, Czeiter E, Duberg D, Sinioja T, Kråkström M, Retel Helmrich IRA, Wang KKW, Maas AIR, Steyerberg EW, Menon DK, Tenovuo O, Hyötyläinen T, Büki A, Orešič M; CENTER-TBI Participants and Investigators. Serum metabolome associated with severity of acute traumatic brain injury. Nat Commun. 2022 May 10;13(1):2545.
  8. Newcombe VFJ, Ashton NJ, Posti JP, Glocker B, Manktelow A, Chatfield DA, Winzeck S, Needham E, Correia MM, Williams GB, Simrén J, Takala RSK, Katila AJ, Maanpää HR, Tallus J, Frantzén J, Blennow K, Tenovuo O, Zetterberg H, Menon DK. Post-acute blood biomarkers and disease progression in traumatic brain injury. Brain. 2022 Apr 4:awac126.
  9. Roine T, Mohammadian M, Hirvonen J, Kurki T, Posti JP, Takala RSK, Newcombe VF, Tallus J, Katila AJ, Maanpää HR, Frantzen J, Menon D, Tenovuo O. Structural Brain Connectivity Correlates with Outcome in Mild Traumatic Brain Injury. J Neurotrauma. 2022 Jan 26.
  10. Iaccarino C, Kolias A, Adelson PD, Rubiano AM, Viaroli E, Buki A, Cinalli G, Fountas K, Khan T, Signoretti S, Waran V, Adeleye AO, Amorim R, Bertuccio A, Cama A, Chesnut RM, De Bonis P, Estraneo A, Figaji A, Florian SI, Formisano R, Frassanito P, Gatos C, Germanò A, Giussani C, Hossain I, Kasprzak P, La Porta F, Lindner D, Maas AIR, Paiva W, Palma P, Park KB, Peretta P, Pompucci A, Posti J, Sengupta SK, Sinha A, Sinha V, Stefini R, Talamonti G, Tasiou A, Zona G, Zucchelli M, Hutchinson PJ, Servadei F. Consensus statement from the international consensus meeting on post-traumatic cranioplasty. Acta Neurochir (Wien). 2021 Feb;163(2):423-440.
  11. Hossain I, Mohammadian M, Takala RSK, Tenovuo O, Ala-Seppälä H, Blennow K, Katila AJ, Kyllönen A, Lagerstedt L, Maanpää HR, Sanchez JC, Tallus J, van Gils M, Zetterberg H, Hutchinson P, Menon DK, Posti JP. Early levels of GFAP and NF-L in predicting the outcome of mild traumatic brain injury. J Neurotrauma. 2019 Jan 8.
  12. Posti JP, Hossain I, Takala RSK, Liedes H, Newcombe V, Outtrim J, Frantzén JP, Newcombe V, Ala- Seppälä, Kyllönen A, Maanpää HR, Tallus J, van Gils M, Hutchinson P, Menon DK, Tenovuo O. Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase-L1 Are Not Specific Biomarkers for Mild CT-Negative Traumatic Brain Injury. J Neurotrauma. 2017 Jan 27.
  13. Orešič M, Posti JP, Kamstrup-Nielsen MH, Takala RSK, Lingsma HF, Mattila I, Jäntti S, Katila AJ, Carpenter KLH, Ala-Seppälä H, Kyllönen A, Maanpää HR, Tallus J, Coles JP, Heino I, Frantzén J, Hutchinson PJ, Menon DK, Tenovuo O, Hyötyläinen T. EBioMedicine. Human serum metabolites associate with severity and patient outcomes in traumatic brain injury. EBioMedicine. 10/2016;12:118-126.